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These mechanisms underpin its therapeutic potential in treating a wide array of conditions, ranging from musculoskeletal injuries to gastrointestinal disorders

doi: 10.3389/fmicb.2022.916089

Early symptoms of the disease can precede the diagnosis by several years, and include constipation (the most common early symptom), REM sleep disorder, hyposmia (smell impairment), pain, and depression (11)